Day to Day
Young Nation
If you nation is fairly young, meaning you still have in nation Strongest Commander events, then the game can get kind of boring. Use this time to build your main city up and kill zombies on the map. You never want more than 2 levels away from main level for any building in your main city. Meaning if you are a c20, every other building, factory, depot, hospital, etc should be at least level 18.
Older Nation
If your nation is done with in nation Strongest Commander and moved on to cross nation Strongest Commander events then this is where the game gets much more fun.
Killing Zombies on Map
Killing zombies on the map and making ruin runs uses up mobility. However killing zombies is the easiest method for getting commmander Xp